total of 825 sweet potato germplasm accessions are preserved until October of 2020 in Guangxi province of China, including 549 landraces, 266 cultivars, 69 breeding lines, two wild relatives as well as ten accessions without passport information. Out of them, 586 accessions have been registered into germplasm resource nursery in Guangxi. The characterization of the agronomic characters, dry matter content and yield in the whole panel, as well as the quality-related traits and disease resistance in a sub-panel lead to the identification of 126 elite accessions. The preservation and Renewal Technology of Sweet Potato Germplasm Resources has been improved. The data management system containing 5107 and 10202 data points regarding to the qualitative and quantitative traits, respectively, has been established. Based on the genetic diversity analysis of 486 sweet potatoes, we established a core germplasm collection with 122 accessions. Thirty-three new sweet potato varieties have been released by taking use of these germplasm accessions. The application of new varieties in agriculture resulted in remarkable economic, social and ecological benefits.