Malnutrion of iron（Fe）and zinc (Zn) minerals has been one of the most essential causes of harm to human health.Wheat (Triticum aestivum L.) is one of the important staple crops as the resources of both foods and minerals. However, low content of Fe and Zn in wheat grains has caused great concerns to international scientists. Breeding of new wheat cultivars, which are rich in mineral content, is regarded as the most economical and sustainable approach to overcome mineral malnutrition. In this paper, current researches on the genetic difference, influence factors and the molecular mechanism of micronutrient enrichment were reviewed. Additionally，the perspective of research on wheat Fe and Zn quality was outlined．