Soybean mosaic virus （SMV） occurs in nearly all soybean-growing areas worldwide and it causes severe yield loss and seed quality reduction in soybean. This review summarizes the recent progress in identification of SMV resistance genes and linked molecular markers， and discusses pyramiding of multiple molecular markers to facilitate breeding of soybean varieties resistant to SMV， and analyzes physical position of SMV resistance genes， for example R_SC3（w）、R_SC14-r and R_SC18 etc. Many candidate genes （such as GsCAD1， GmCAL and GmMLRK1） were proposed based on sequence variation， quantitative real-time polymerase chain reaction （qRT-PCR）， virus induced gene silencing （VIGS） and CRISPR （clustered regularly interspersed short palindromic repeats）/Cas9. Collectively， this study highlights the molecular mechanism of SMV-soybean interactions， e.g. the progress of the Rsv3 gene conferring SMV resistance， and provides perspectives for future studies via applying the markers or mechanism for SMV resistance breeding.