India is the one of the richest biodiversity country in the global which the claims is the national sovereignty over genetic resource and benefit-sharing on it. India have stipulated the Act on Biodiversity in 2003, the Regulation on Biodiversity in 2004 including the issue like the nation has the sovereignty right on genetic resource and associated with traditional knowledge, the principle of protection, the competent authority and administrative regulation system and benefit-sharing, ect and the Guidelines on Access to Biological Resource and Associated Knowledge and Benefit Sharing Regulations in 2014 rules that bioprospecting and access to biological resource, the form and ratios of merchandises, the procedure of results transfer the application to IP and benefit-sharing, the transfer to third-party or merchandise and exemption approvals. This paper summarize the development process on regime system of genetic resource and associated with traditional knowledge of India and analysis or conclude the measures on regimes in different steps. The process mentioned above in India is step by step and to go completely and specific. The same situation in national and international negotiation between India and China in this field, the pathway of India in this field can be brought to China for research and reference.