There are 33 wild orchids listed in the national first-class plant protection catalog, belonging to several genera including Paphiopedilum, Cypripedium, Cymbidium, Dendrobium, Phalaenopsis, and Calanthe, which have important ornamental and medicinal value. The registration status of hybrids, their parents selection, pollination and sowing time selection, intergeneric hybridization progress and problems in hybrid breeding of these species have been reviewed. Based on the current breeding situation, future breeding directions are proposed. It shown that 3611 hybrid combinations with the national first-class wild orchids as parents have been registered in RHS. The top ten species of hybrid combinations are Paphiopedilum spp., followed by Cymbidium insigne. However, no hybrid combinations have been registered with Paphiopedilum erythroanthum, Paphiopedilum guangdongense, Paphiopedilum notatisepalum, and Cypripedium subtropicum as parents. There are few hybrid combinations with Paphiopedilum hangianum, Dendrobium flexicaule, Dendrobium huoshanense, Cymbidium wenshanense as parents, although they are all excellent germplasm resources with great potential. It suggested that we should make full use of the above wild germplasm resources, strengthen intergeneric hybridization, and use molecular marker assisted breeding to accelerate the cultivation of new varieties in the future, so as to improve the utilization level of wild orchid germplasm resources. This article can provide reference for the hybrid breeding of the national first-class wild orchids, and provide support for the innovation of orchid germplasm resources and the sustainable development of the orchid industry.