The resistance of 116 wheat varieties collected from the wheat-producing area of Huang-Huai to Fusarium pseudograminearum (Fp) and F. graminearum (Fg) was evaluated by means of artificial inoculation indoors at seedling stage and single flower instillation inoculation at heading stage in the field. Indoor evaluation results showed that none of the varieties were imunne or highly resistant against Fp and Fg. Against Fp, 3 varieties (2.59% of the total) were moderately resistant, 10 varieties (8.62% of the total) were susceptible, and 103 varieties (88.79% of the total) were highly susceptible. Against Fg, 23 varieties (19.83% of the total) were moderately resistant, 50 varieties (43.10% of the total) were susceptible, and 43 varieties (37.07% of the total) were highly susceptible. Field evaluation results showed that against Fp, 6 varieties (5.17% of the total) were resistant, 10 varieties (8.62% of the total) were moderately resistant, 62 varieties (53.45% of the total) were moderately susceptible, 34 varieties (29.31% of the total) were susceptible, 4 varieties (3.45% of the total) were highly susceptible. Against Fg, 1 variety (Sumai 3) (0.86% of the total) was resistant, 2 varieties (Tunmai 127 and Xinmai 208) (1.72% of the total) were moderately resistant, 37 varieties (31.90% of the total) were moderately susceptible, 49 varieties (42.24% of the total) were susceptible, and 26 varieties (22.41% of the total) were highly susceptible. The tested varieties showed different patterns of resistance against Fp and Fg in different stages, with relatively fewer varieties resistant against Fp than against Fg treated with artificial inoculation indoors in seedling stage, and relatively fewer varieties resistant against Fg than against Fp treated with single flower instillation inoculation in the field in heading stage.