Six main agronomic traits and Yield per plant(Y) of ninety main cotton germplasm resources in China were measured at flowering and boll setting stage- under drought stress. Comprehensive drought resistance coefficient(CDC value), factor analysis, subordinate function coefficients, clustering analysis, grey relational analysis , broad-sense heritability were used to evaluate the drought resistance, classify drought resistance and select evaluation indices in tested cottons. D value based on traits related to drought stress were Correlation degree of order bits : Yield per plant(Y), Effective number , Effective fruit branch number , Plant height , Single boll weight , Lint percentage , Initial internodes of fruiting branch .Factor analysis showed that three common factors could represent 72.45% of the original information of cotton drought resistance data. The ranks of drought resistance of tested cotton sbased on drought resistance comprehensive evaluation values (D value) and weight drought resistance coefficient (WDC value) were similar. D values of tested cottons correlated positively with CDC value, WDC value and Y value.Broad-sense heritability showed that the highest rate of genetic generalized D value was 55.4%, followed by CDC value, WDC value. Y values of tested cotton salso had very significant and positive correlation with CDC value and WDC value. Tested cultivars were divided into five drought grades according to D value, and reflected the variety of breeding conditions and adaptation to regional well. Based on the comprehensive index of drought resistance, the size of heritability D value was the main parameter, assisted by WDC for evaluation parameters, with evaluation of the yield per plant as the main consideration goal, yield drought resistance of cotton were appropriate and necessary. Drought resistance comprehensive evaluation methods used in studying comprehensive evaluation of drought resistance drought resistant and screening evaluation indices in cotton were feasible and effective.